What's Happening?
An international research team has identified ANKLE1, a human protein, as the first DNA-cutting enzyme in mammals capable of detecting and responding to physical tension in DNA. This discovery, published in Nature Communications, highlights ANKLE1's role
in maintaining genetic integrity during cell division, a process crucial for preventing cancer and other diseases. The study was conducted by researchers from the University of Hong Kong, Shenzhen Bay Laboratory, and other institutions. ANKLE1 acts as a 'tension sensor' nuclease, cutting DNA only when it is under tension, thus preventing random breaks that could lead to genetic instability.
Why It's Important?
The discovery of ANKLE1's tension-sensing capabilities is a significant advancement in understanding how cells protect their genetic material during division. This mechanism is vital for preventing DNA breaks that can lead to cancer and immune disorders. The research provides insights into genome stability and suggests that targeting ANKLE1 could enhance cancer therapies by exploiting tumor vulnerabilities. This finding opens new avenues for therapeutic strategies and deepens the understanding of cellular responses to mechanical stress on DNA.
