What's Happening?
Research from the University of Cambridge reveals that a widely used IVF test, preimplantation genetic testing for aneuploidy (PGT-A), may miss genetic abnormalities that develop in embryos just before
implantation. The study involved monitoring human embryos for 46 hours after thawing, using a light-sheet microscope to reduce light exposure and allow longer observation. Researchers found that 8% of cells experienced chromosome misalignment, which can lead to genetic abnormalities. These errors were confined to the outer layer of cells, which form the placenta, suggesting they may not affect embryo viability.
Why It's Important?
This discovery raises questions about the reliability of current genetic screening methods in IVF procedures. While genetic abnormalities in outer cells may not impact embryo viability, the findings suggest a need for improved screening techniques to ensure the selection of embryos with the best chance of developing into healthy pregnancies. This could influence fertility clinics and patients in making informed decisions about IVF treatments, potentially leading to advancements in reproductive technology and genetic testing protocols.
