What's Happening?
Corinne Hazel, an environmental microbiology major from Delaware, Ohio, has discovered a new species of fungus named Periglandula clandestina. This fungus, found in morning glory plants, produces ergot alkaloids similar to those modified by Swiss chemist Albert Hofmann when he invented LSD in the late 1930s. Hazel's discovery was made while studying the dispersal of protective chemicals in morning glories, leading to the identification of the elusive fungus. The research, conducted with Daniel Panaccione at WVU Davis College, has confirmed the fungus's ability to produce ergot alkaloids in large quantities, which could have significant implications for pharmaceutical development.
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Why It's Important?
The discovery of Periglandula clandestina is significant due to its potential applications in treating conditions such as depression, PTSD, and addiction. Ergot alkaloids, produced exclusively by fungi, are used therapeutically to treat migraines, dementia, and Parkinson's disease, despite their potential side effects. Hazel's research opens new avenues for pharmaceutical exploration, particularly in the efficient production of these alkaloids. The ability to culture the fungus and explore its presence in other morning glory species could lead to breakthroughs in medical treatments, benefiting both the pharmaceutical industry and patients with various health conditions.
What's Next?
Hazel is currently focused on studying the most effective methods to culture the slow-growing Periglandula clandestina. Her research aims to determine whether other morning glory species also contain ergot alkaloids from similar fungal symbiotes. The findings could lead to further discoveries and advancements in the production of ergot alkaloids, potentially revolutionizing their use in pharmaceuticals. Continued research and genome sequencing will be crucial in understanding the full capabilities and applications of this newly discovered fungus.
Beyond the Headlines
The discovery of Periglandula clandestina highlights the intricate symbiotic relationships between plants and fungi, offering insights into ecological interactions and evolutionary biology. The ability of fungi to produce complex alkaloids raises questions about their role in natural ecosystems and their potential for biotechnological applications. Ethical considerations regarding the use of such compounds in medicine and their historical association with substances like LSD may also emerge as research progresses.
